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Friday, December 05, 2008
 
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   Hepatitis B

Description
  • Hepatitis refers to an inflammation of the liver. Hepatitis B is a specific type of hepatitis caused by the hepatitis B virus, which is usually transmitted by blood products, or sexually. Hepatitis B can cause an acute infection or a chronic (persistent) one.


Risk Factors
  • Homosexual behavior
  • Intravenous drug abuse
  • Medical professionals
  • Hemodialysis workers
  • Infants of mothers with hepatitis B


Symptoms

First phase (lasts 2-3 weeks):
  • Fatigue
  • Not "feeling well"
  • Loss of appetite
  • Nasal discharge
  • Sore throat
  • Skin rashes
  • Joint pain
  • Fever or chills
  • Nausea/vomiting
  • Abdominal pain
  • Diarrhea or constipation

Second (Icteric) phase (occurs 5-10 days after first phase):
  • Yellow skin or eyes
  • Usually other symptoms improve
  • Third (convalescent) phase:
  • Continued steady improvement
  • Chronic persistent hepatitis:
  • May have none
  • Fatigue
  • Loss of appetite
  • Chronic active hepatitis:
  • May have none
  • Fatigue
  • Yellow skin or eyes may be present


Diagnosis
  • Skin-yellow skin or eyes
  • Liver tenderness
  • Spleen tenderness
  • Elevated AST, ALT, and total bilirubin
  • Hepatitis B antibody testing to confirm diagnosis
  • Acute: positive HBsAg, HbeAg, Anti-HBc IgM
  • Chronic persistent: positive HBsAg, positive Anti-Hbe IgG
  • Chronic active hepatitis: positive HBsAg, Anti HBc IgG (& low levels IgM), HbeAg
  • Liver biopsy to diagnose chronic forms


Similar Conditions
  • Mononucleosis
  • Hepatitis A
  • Hepatitis C
  • Cytomegalovirus
  • Q fever
  • Drug-induced liver disease
  • Secondary syphilis
  • Cholecystitis
  • Alcoholic hepatitis
  • Autoimmune hepatitis


Complications
  • Infection with delta agent. This is a secondary agent on top of the infection with hepatitis B. It can make the infection much more severe. Diagnosis is made by checking for anti-HDV in the blood.
  • Hepatocellular (liver) cancer-patients who have been infected with hepatitis B are at much higher risk of developing liver cancer
  • Liver cirrhosis


Treatment
  • Acute hepatitis:
  • Avoid Tylenol and alcoholic beverages. Bed rest as needed. No medical treatment.
  • Chronic active hepatitis:
  • Alpha-Interferon
  • Lamivudine


Prevention
  • Hepatitis B vaccine:
  • Hepatitis B vaccine now exists and is routinely given during childhood immunizations. It is also given to high-risk adults, e.g., medical professionals.
  • Hepatitis B immune globulin immunization for pregnant mothers
  • Universal blood precautions
  • Condoms may reduce or eliminate the chances of contracting hepatitis B from sexual relations.



 


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